HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 16069053, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 57692750 | HCID 57692750 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16069053 | HCID 16069053 | — |
Reaction Steps
To a solution of N1,N1-diisopropyl-3-phenyl-2-pyridin-3-ylpentanediamide (90 mg, 0.245 mmol) in 1 mL DMF was added SOCl2 (0.5 mL) and heated at 90 C for 45 min. Concentrated (azeotroped 2× from benzene) and purified by r.p. HPLC. Desired fractions from HPLC were combined and the product was isolated as free base. White solid, single diastereomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278317B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4b295cbafecc4ab9ae880cfdcdb9ad47 |
| Source note | uspto-grants-2012_10 |