HRID2059837

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCNC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1

HCID59868917

未命名化合物

结构：O=C1N([C@H]2CC[C@@H](O)CC2)CC[C@]12CCCN(c1ccc(Br)cc1F)C2

HCID178517853

未命名化合物

PRODUCTS

生成物

结构：CCNC(=O)c1ccc(-c2ccc(N3CCC[C@]4(CCN([C@H]5CC[C@@H](O)CC5)C4=O)C3)c(F)c2)cn1

HCID178464738

未命名化合物

PROCEDURE

实验过程

This compound was prepared by using procedures that were analogous to those described for the synthesis of Example 1, Step 8 starting from N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide and (5S)-7-(4-bromo-2-fluorophenyl)-2-(cis-4-hydroxycyclohexyl)-2,7-diazaspiro[4.5]decan-1-on. LC/MS m/e 495.3 (M+H)+.

WORKUP

后处理

customThis compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-abb5803e1715471c9c50fc2f9fa3a983
来源数据集: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08278318B2
来源说明: uspto-grants-2012_10

反应 SMILES

[CH2:1]([NH:3][C:4]([C:6]1[CH:11]=[CH:10][C:9](B2OC(C)(C)C(C)(C)O2)=[CH:8][N:7]=1)=[O:5])[CH3:2].Br[C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:45][CH2:44][CH2:43][C@@:30]3([C:34](=[O:35])[N:33]([C@H:36]4[CH2:41][CH2:40][C@@H:39]([OH:42])[CH2:38][CH2:37]4)[CH2:32][CH2:31]3)[CH2:29]2)=[C:24]([F:46])[CH:23]=1>>[CH2:1]([NH:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:22]2[CH:27]=[CH:26][C:25]([N:28]3[CH2:45][CH2:44][CH2:43][C@@:30]4([C:34](=[O:35])[N:33]([C@H:36]5[CH2:37][CH2:38][C@@H:39]([OH:42])[CH2:40][CH2:41]5)[CH2:32][CH2:31]4)[CH2:29]3)=[C:24]([F:46])[CH:23]=2)=[CH:8][N:7]=1)=[O:5])[CH3:2]