Trifluoroacetic acid → HCID 58579905, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-((4-chlorophenylthio)methyl)-6-oxopyridazine-1(6H)-carboxylate Part C (137 mg, 0.34 mmol) in CH2Cl2 (5 mL) was added TFA (1.50 mL, 19.41 mmol). The mixture was stirred at RT for 15 min before being concentrated. The crude product was subjected to flash chromatography (silica gel/hexane-EtOAc 100:0 to 0:100 gradient, using LC-MS to identify fractions containing the desired product) to afford 5-((4-chlorophenylthio)methyl)pyridazin-3(2H)-one 7D (81 mg, 81% yield). 1H NMR (400 MHz, Chloroform-D) δ ppm 7.76 (1H, d, J=2.01 Hz), 7.27 (4H, s), 6.56 (1H, s), 3.82 (2H, s).

Provenance & Evidence