反应详情

N-arylation of 6-((4-chlorophenylthio)methyl)pyrimidin-4(3H)-one Part B of Procedure 10 with 2-(4-bromo-2-methoxyphenoxy)-1-cyclopropylethanol Part C to generate G-2 was achieved using the procedure described in Part C of Procedure 10. LC/MS 459 (M+H)+, tR 0.97 min (method 5). 1H NMR (400 MHz, Chloroform-D) δ ppm 8.14 (1H, s), 7.26-7.40 (4H, m), 7.03 (1H, d), 6.80-6.91 (2H, m), 6.45 (1H, s), 4.20 (1H, dd, J=9.54, 2.76 Hz), 4.03 (1H, t, J=8.91 Hz), 3.96 (2H, s), 3.87 (3H, s), 3.36 (1H, td, J=8.34, 2.64 Hz), 0.91-1.06 (1H, m), 0.51-0.67 (2H, m), 0.40-0.50 (1H, m), 0.26-0.37 (1H, m).