反应详情

Thionyl chloride (5.5 ml, 75 mmol) was added to a solution of 2-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester (6 g, 25 mmol) in methanol (60 ml) while stirring and the mixture was then refluxed for 16 h. The solvent was removed under vacuum and the crude product used in the next stage without purification. Yield: 90%

1. temperaturethe mixture was then refluxed for 16 h
2. customThe solvent was removed under vacuum
3. customthe crude product used in the next stage without purification