HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxaspiro[4.5]decan-8-one → 8-(3-fluorophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | HCID 59311794 | HCID 59311794 | — |
| Reactant | HCID 178505844 | HCID 178505844 | — |
| Product | 8-(3-fluorophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amine | HCID 57475110 | — |
Reaction Steps
The reaction was performed starting from 1,4-dioxaspiro[4.5]decan-8-one and 4-fluorophenylmagnesium chloride (1 M in hexane) in an analogous manner to stage 1 amine (A1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278319B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-e9c37336c01a403c9556393d9c38fe48 |
| Source note | uspto-grants-2012_10 |