Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → tert-Butyl 4-formylpiperidine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

To the solution of tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate (139.5 mmol) in DCM (300 ml) was added PCC (209.3 mmol, 1.5 eq) at 0° C. The reaction mixture was then allowed to stir at 25° C. for 16 h. The mixture was filtered through celite, washed with DCM (2×200 ml), and the organics were concentrated and purified by silica gel column chromatography (10% EtOAc in DCM) to obtain the desired compound. Yield: 42%

Provenance & Evidence