Tert-butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate → tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate

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Reaction Steps

tert-Butyl 9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylate (6.41 mmol, 1 eq) was taken up in ethanol (500 ml) and to the mixture was added 10% Pd/C (3.4 g). The mixture was hydrogenated at 25° C. for 16 h. The reaction mixture was filtered through celite, concentrated and purified by silica gel column chromatography to yield the desired product. Yield: 38%

Provenance & Evidence