Hydrate;hydrochloride → 3-Aza-spiro[5.5]undecan-9-one hydrochloride

HRID 2059920Notes

Reaction equation

HRID 2059920 reaction equation
[O:1]=[C:2]1[CH2:19][CH2:18][C:5]2([CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]2)[CH2:4][CH:3]1C(OC)=O.[ClH:24].O>>[ClH:24].[CH2:10]1[C:5]2([CH2:18][CH2:19][C:2](=[O:1])[CH2:3][CH2:4]2)[CH2:6][CH2:7][NH:8][CH2:9]1

Participants

3

Reactant 2

HCID 21885828Hydrate;hydrochlorideHCID 67315804HCID 67315804, compound

Product 1

HCID 673158423-Aza-spiro[5.5]undecan-9-one hydrochloride

Procedure

To 3-tert-butyl 8-methyl 9-oxo-3-azaspiro[5.5]undecane-3,8-dicarboxylate (450 mg, 1.38 mmol) was added HCl—H2O (5 ml, 1:1) at 0° C. and the mixture was refluxed overnight. LCMS revealed complete consumption of the starting material and the mixture was concentrated to dryness. The crude product thus obtained was used directly in next step.

Workup

  1. temperaturethe mixture was refluxed overnight
  2. customconsumption of the starting material
  3. concentrationthe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-67fe3e5ed43e4967bd792dcb48cac8bd
Source dataset
uspto-grants-2012_10
Patent number
US08278319B2

Reaction notes

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