HCID 67315659, compound → HCID 86641305, compound

Participants

Reaction Steps

The crude tert-butyl 9-cyano-9-(3,3-difluoroazetidin-1-yl)-3-azaspiro[5.5]-undecane-3-carboxylate was taken up in THF (20 ml) and PhMgBr (12 ml) was added at 0° C. The reaction mixture was stirred at room temperature overnight. The mixture was quenched with NH4Cl solution at 0° C. and was then extracted with ethyl acetate. The organic layer was washed with brine, dried over Na2SO4, concentrated and purified by column chromatography (silica gel (100-200)) to obtain the desired compound. Yield: 31%

Provenance & Evidence