HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (2-Chloro-6-methoxypyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Fluoroindoline | HCID 2774463 | — |
| Reactant | 2-Chloro-6-methoxypyridine-4-carboxylic acid | HCID 2782124 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (2-Chloro-6-methoxypyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386441 | — |
Reaction Steps
0.965 g (3.00 mmol) TBTU was added at RT to 0.500 g (2.67 mmol) 2-chloro-6-methoxyisonicotinic acid, 0.366 g (2.67 mmol) 5-fluoroindoline and 0.421 mL (3.00 mmol) triethylamine in 10.0 mL DMF. The mixture was stirred for 2 h at RT and then purified by preparative HPLC. The fractions containing the product were combined and evaporated down i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278336B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4a9abb9d2279475e90dbd8dd1ba54ebd |
| Source note | uspto-grants-2012_10 |