HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Fluoro-3,3-dimethylindolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 58386657 | HCID 58386657 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-Fluoro-3,3-dimethylindolin-2-one | HCID 45139409 | — |
Reaction Steps
2.10 g (9.49 mmol) 1-acetyl-5-fluoro-3,3-dimethyl-1,3-dihydro-indol-2-one in 20 mL isopropanol were refluxed with 50 mL of a 6M aqueous HCl solution for 1 h. After cooling the isopropanol was eliminated i. vac. The residue was diluted with water and cooled with ice. The precipitated substance was suction filtered and washed with water. The solid was dried i. vac.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278336B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-5e94ab15af6048da8418ccc39597e635 |
| Source note | uspto-grants-2012_10 |