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HRID 2059978作成日：2026年10月25日
Potassium Carbonate → 1-[4'-(5-fluoro-2,3-dihydroindole-1-carbonyl)-6'-methoxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-1,3-dihydroimidazo[4,5-b]pyridin-2-one
https://huagongshe.com/reaction/2059978
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
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| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(piperidin-4-yl)-1H,2H,3H-imidazo[4,5-b]pyridin-2-one dihydrochloride | HCID 22293181 | — |
| 反応物 | (2-Chloro-6-methoxypyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386441 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 1-[4'-(5-fluoro-2,3-dihydroindole-1-carbonyl)-6'-methoxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl]-1,3-dihydroimidazo[4,5-b]pyridin-2-one | HCID 58386522 | — |
反応手順
A mixture of 0.361 g (1.24 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one dihydrochloride, 0.380 mg (1.24 mmol) (2-chloro-6-methoxypyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone and 514 mg (3.72 mmol) potassium carbonate in 3.0 mL NMP was stirred for 8 h at 130° C. After cooling the reaction mixture to RT the precipitate formed was filtered off and purified by preparative HPLC. The fractions containing the product were combined and evaporated down i. vac.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08278336B2 |
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| 出典データセット | uspto-grants-2012_10 |
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| ORD ID | ord-7091dda13bc5447eb14fa5c90ec053bf |
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| 出典メモ | uspto-grants-2012_10 |
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