Bms-973013 → 1-[4'-(4,5-Difluoro-2,3-dihydro-indole-1-carbonyl)-6'-methoxy-3,4,5,6-tetra-hydro-2H-[1,2]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Participants

Reaction Steps

0.982 g (4.50 mmol) 1-Piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one and 500 mg (1.54 mmol) (2-chloro-6-methoxy-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone in 3.0 mL NMP were stirred for 12 h at 130° C. After the reaction mixture had cooled to RT the precipitate formed was filtered off and purified by preparative HPLC. The product-containing fractions were combined and lyophilised.

Provenance & Evidence