HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (4-Chloro-6-methoxy-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 5-Fluoroindoline | HCID 2774463 | — |
| Reactant | HCID 86313539 | HCID 86313539 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (4-Chloro-6-methoxy-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58386681 | — |
Reaction Steps
550 mg (2.93 mmol) 4-chloro-6-methoxy-pyridine-2-carboxylate, 411 mg (3.00 mmol) 5-fluoroindoline, 1.06 g (3.30 mmol) TBTU and 927 μL (6.60 mmol) triethylamine in 5.00 mL DMF were stirred for 3 h at RT. The reaction mixture was purified by HPLC. The product-containing fractions were combined and evaporated down using the rotary evaporator.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278336B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-77d929a064224fbb9a7df6e7845863ba |
| Source note | uspto-grants-2012_10 |