Methyl iodide → 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

HRID 2059990Notes

Reaction equation

HRID 2059990 reaction equation
[I:1][CH3:2].[CH2:3]([N:5]1[CH2:10][CH2:9][C:8](=[O:11])[CH2:7][CH2:6]1)[CH3:4]>CC(C)=O>[I-:1].[CH2:3]([N+:5]1([CH3:2])[CH2:10][CH2:9][C:8](=[O:11])[CH2:7][CH2:6]1)[CH3:4]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 771591-Ethylpiperidin-4-one

Product 1

HCID 110975681-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Iodomethane (65 mL; 1.00 mol) was added in portions to a solution of 1-ethyl-4-piperidone (100 g; 0.79 mol) in acetone (1 L) at 20-30° C. (internal, ice cooling). After stirring for 3 h more the title compound was obtained by filtration, and washing with acetone (189 g).

Sources & evidence

ORD record
ord-11c5b04713c64ab3aeb6c231ad865fad
Source dataset
uspto-grants-2012_10
Patent number
US08278328B2

Reaction notes

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