HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-Amino-5-hydroxy-2-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 5-Hydroxy-2-methyl-4-nitrobenzonitrile | HCID 59444174 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-5-hydroxy-2-methylbenzonitrile | HCID 55284402 | 98.6% |
Reaction Steps
5-hydroxy-2-methyl-4-nitrobenzonitrile (D91, 185 mg, 1.04 mmol) was dissolved in EtOH:EtOAc (24 mL, 1:1) and was reduced using an H-Cube (full H2 mode, 25° C., 1 mL/min). The reaction was concentrated by rotary evaporation to give 4-amino-5-hydroxy-2-methylbenzonitrile (D92, 152 mg, 95%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278328B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-1598665abb3b460592468d5482124467 |
| Source note | uspto-grants-2012_10 |