Sodium Hydroxide → HCID 68805219, compound

HRID 2060066Notes

Reaction equation

HRID 2060066 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:15])[CH:12]=2)[C:7]1=[O:16])[CH3:4].[OH-].[Na+]>O>[CH3:4][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:15])[CH:12]=2)[C:7]1=[O:16])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69450977HCID 69450977, compound

Product 1

HCID 68805219HCID 68805219, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.8 g of 2-dimethylaminomethyl-5-fluoro-indan-1-one hydrochloride were dissolved in water; the solution was adjusted to pH 12 with 32% sodium hydroxide solution, while cooling with ice, and extracted three times with dichloromethane, and the combined organic phases were dried over magnesium sulfate, filtered and concentrated in vacuo.

Workup

  1. temperaturewhile cooling with ice
  2. extractionextracted three times with dichloromethane
  3. dry with materialthe combined organic phases were dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bef25111f6c44042ac60b55c67746e3b
Source dataset
uspto-grants-2012_10
Patent number
US08278338B2

Reaction notes

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