Hydrochloric Acid → HCID 69449242, compound

Participants

Reaction Steps

About 5.4 ml of 37% hydrochloric acid were added at room temperature to 0.5 g of 2-dimethylaminomethyl-5-fluoro-1-pyridin-3-yl-indan-1-ol hydrochloride (mixture of the diastereoisomers); stirring was carried out overnight, followed by concentration in vacuo. The residue was taken up twice in dichloromethane and concentrated again. The residue was taken up in 15 ml of acetone and stirred for 2 hours, whereupon a crystalline solid formed, which was filtered off with suction, with the exclusion of air, washed twice with diethyl ether and dried at 60° C. under an oil-pump vacuum. 0.39 g of (6-fluoro-3-pyridin-3-yl-1H-inden-2-ylmethyl)-dimethyl-amine hydrochloride was obtained.

Provenance & Evidence