HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(Aminomethyl)-5-bromopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-(Azidomethyl)-5-bromopyridine | HCID 57640538 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(Aminomethyl)-5-bromopyridine | HCID 22992264 | — |
Reaction Steps
To a solution of 3-azidomethyl-5-bromo-pyridine 250 (1.49 g, 7.00 mmol, 1.00 equiv) in 1,4-dioxane (12 mL) was added water (1 mL) and triphenylphosphine resin (2.08 g, 3 mol/g, 200-400 mesh, 1.2 equiv). The suspension was stirred overnight. Filtration and concentration afforded C-(5-bromo-pyridin-3-yl)-methylamine 251.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278337B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c55af4320ab04c0687036b976acfaa53 |
| Source note | uspto-grants-2012_10 |