HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → HCID 59406376, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59588368 | HCID 59588368 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59406376 | HCID 59406376 | — |
Reaction Steps
To a solution of 6-hydroxypicolinic 265 (0.14 g, 1.0 mmol, 1.00 equiv), (6-aminomethyl-benzothiazol-2-yl)-carbamic acid tert-butyl ester (0.28 g, 1.0 mmol, 1.0 equiv) and N,N-diisopropylethylamine (0.35 mL, 2.0 mmol, 2.0 equiv) in NMP (2.5 mL) at room temperature was added HATU (0.38 g, 1.0 mmol, 1.0 equiv) in one portion. The reaction mixture was stirred at room temperature for 2 hours, diluted with ethyl acetate and washed with water, brine, dried (sodium sulfate) and concentrated affording 6-methoxy-pyridine-2-carboxylic acid (2-amino-benzothiazol-6-ylmethyl)-amide 266. LCMS: (MH—C4H8)+=345.0 (1.55 min). (See Table 24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278337B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-065ae7a86ffd4fd4b0b8cedc5b4d21de |
| Source note | uspto-grants-2012_10 |