HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2060202Generated: November 1, 2026
Triethylamine → 5-Methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester
https://huagongshe.com/reaction/2060202
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 5-Hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester | HCID 57990210 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Methanesulfonyloxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester | HCID 57990212 | — |
Reaction Steps
To a cooled solution (5° C.) of 5-hydroxymethyl-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester (11 Kg, 38.8 mol, step 7) and Et3N (7.04 L, 50.6 mol) in DCM (55 L) was added methanesulphonyl chloride (2.97 L, 38.4 mol) so that the internal temp <10° C. After stirring for 0.5 h at 5° C. the solution was used below in step 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08277807B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-fc0066ee24bf47c0b9ace9b56761b236 |
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| Source note | uspto-grants-2012_10 |
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