2,2,2-Trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethan-1-one → 2,2,2-trichloro-1-(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)ethan-1-one

HRID 2060218노트

반응식

HRID 2060218 반응식
[Cl:1][C:2]([Cl:13])([Cl:12])[C:3]([C:5]1[NH:6][C:7]([Br:11])=[C:8]([Br:10])[CH:9]=1)=[O:4].Cl.N[C:16]1NC=C(CCCC(NCCCCCCCCCCCC)=O)N=1>>[Cl:13][C:2]([Cl:1])([Cl:12])[C:3]([C:5]1[N:6]([CH3:16])[C:7]([Br:11])=[C:8]([Br:10])[CH:9]=1)=[O:4]

참가 물질

3

반응물 2

HCID 27633462,2,2-Trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethan-1-oneHCID 178443255HCID 178443255, 화합물

생성물 1

HCID 579144012,2,2-trichloro-1-(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)ethan-1-one수율 96%

실험 절차

Using the same general procedure as used for the synthesis of 2,2,2-trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)-ethanone 8, 5.00 g of 2-trichloroacetyl-1-methylpyrrole 12 gave 8.14 g (96%) of the title compound 14 as white needles. 1H NMR (300 MHz, DMSO-d6) δ 7.60 (s, 1H), 3.96 (s, 3H); 13C NMR (100 MHz, DMSO-d6) δ 170.86, 123.81, 122.68, 120.58, 99.58, 94.89, 37.60; HRMS (FAB) calcd for C7H4Br2Cl3NO (M+) 380.7725. found 380.7744.

출처 및 근거

ORD 기록
ord-15084f3880b14a53b7af5c6a511f2c85
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278340B2

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