2-Methoxybenzoyl chloride → 1-(2-Methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

HRID 2060234Notes

Reaction equation

HRID 2060234 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:2].[CH3:11][O:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](Cl)=[O:16]>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][N:8]([C:15](=[O:16])[C:14]2[CH:18]=[CH:19][CH:20]=[CH:21][C:13]=2[O:12][CH3:11])[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 889692-Methoxybenzoyl chlorideHCID 12896002Ethyl pyrrolidine-3-carboxylate

Product 1

HCID 593222021-(2-Methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl esterYield 68%

Procedure

The title compound was prepared according to the method described for Preparation 2 using pyrrolidine-3-carboxylic acid ethyl ester (see Preparation 1) and 2-methoxy-benzoyl chloride to afford the title compound as a colourless oil (4.17 g, 68%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5fe0ec631a1d494c9817abd11ebe5845
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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