2-Ethoxybenzoyl chloride → 1-(2-Ethoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

HRID 2060235Notes

Reaction equation

HRID 2060235 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:2].[CH2:11]([O:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17])[CH3:12]>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][N:8]([C:16](=[O:17])[C:15]2[CH:19]=[CH:20][CH:21]=[CH:22][C:14]=2[O:13][CH2:11][CH3:12])[CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 30163972-Ethoxybenzoyl chlorideHCID 12896002Ethyl pyrrolidine-3-carboxylate

Product 1

HCID 593221811-(2-Ethoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl esterYield 83%

Procedure

The title compound was prepared according to the method described for Preparation 2 using pyrrolidine-3-carboxylic acid ethyl ester (see Preparation 1) and 2-ethoxy-benzoyl chloride to afford the title compound as a pale yellow oil (5.13 g, 83%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-5e77c7e39a32448e9f3d159b16158cc4
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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