4-Cyanophenylboronic acid → 4-(5-Hydroxypyridin-2-yl)benzonitrile

HRID 2060247Notes

Reaction equation

HRID 2060247 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][N:3]=1.[C:9]([C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1)#[N:10]>>[OH:8][C:5]1[CH:6]=[CH:7][C:2]([C:14]2[CH:15]=[CH:16][C:11]([C:9]#[N:10])=[CH:12][CH:13]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 27628652-Bromo-5-hydroxypyridine

Product 1

HCID 532291564-(5-Hydroxypyridin-2-yl)benzonitrileYield 26%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 2-bromo-5-hydroxypyridine and 4-cyanophenylboronic acid to afford the title compound as a yellow solid (300 mg, 26%)

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-01b8289894f04d8d8efe21bf87d51e5c
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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