4-Chlorophenylboronic acid → 2-(4-Chloro-phenyl)-5-methoxy-pyrimidine

HRID 2060249Notes

Reaction equation

HRID 2060249 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][N:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[N:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][N:3]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 5890582-Chloro-5-methoxypyrimidine

Product 1

HCID 593221882-(4-Chloro-phenyl)-5-methoxy-pyrimidineYield 40%

Procedure

The title compound was prepared according to the method described for Preparation 17 using 2-chloro-5-methoxy-pyrimidine and 4-chlorophenylboronic acid to afford the title compound as an off-white solid (4.05 g, 40%)

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-c5e9c6118d4446e28cb705093899ed9f
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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