HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Chlorophenyl)pyridin-3-ol → 3-[6-(4-Chloro-phenyl)-pyridin-3-yloxymethyl]-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Chlorophenyl)pyridin-3-ol | HCID 53229268 | — |
| Reactant | 1-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322211 | — |
| Product | 3-[6-(4-Chloro-phenyl)-pyridin-3-yloxymethyl]-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322220 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 6-(4-chloro-phenyl)-pyridin-3-ol (Preparation 23) and 1-(4-fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 12) to afford the racemate as a pale yellow solid (128 mg, 53.6%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-68bfe146176b492f804d26bcb9a5e71e |
| Source note | uspto-grants-2012_10 |