HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(4-Chlorophenyl)pyrimidin-5-ol → 3-[2-(4-Chloro-phenyl)-pyrimidin-5-yloxymethyl]-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(4-Chlorophenyl)pyrimidin-5-ol | HCID 59322178 | — |
| Edukt | 1-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322211 | — |
| Produkt | 3-[2-(4-Chloro-phenyl)-pyrimidin-5-yloxymethyl]-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322176 | — |
Reaktionsschritte
The title compound was prepared according to the method described for Preparation 29 using 2-(4-chloro-phenyl)-pyrimidin-5-ol (Preparation 27) and 1-(4-fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 12) to afford the racemate as a pale yellow solid (89 mg, 37%)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08278343B2 |
| Quelldatensatz | uspto-grants-2012_10 |
| ORD ID | ord-d3de812025c043eeb31b694067f5b40d |
| Quellennotiz | uspto-grants-2012_10 |