HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Hydroxy-4-biphenylcarbonitrile → 1-(4-Chloro-benzoyl)-3-(4'-cyano-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Hydroxy-4-biphenylcarbonitrile | HCID 140610 | — |
| Reactant | 1-(4-Chloro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322180 | — |
| Product | 1-(4-Chloro-benzoyl)-3-(4'-cyano-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322234 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 1-(4-chloro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 13) and 4′-hydroxy-4-biphenyl carbonitrile to afford the racemate as a white solid (181 mg, 79.6%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-7c00c94685924924858825f617bc7968 |
| Source note | uspto-grants-2012_10 |