HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Hydroxypyridin-2-yl)benzonitrile → 3-[6-(4-Cyano-phenyl)-pyridin-3-yloxymethyl]-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Hydroxypyridin-2-yl)benzonitrile | HCID 53229156 | — |
| Reactant | 3-Iodomethyl-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322172 | — |
| Product | 3-[6-(4-Cyano-phenyl)-pyridin-3-yloxymethyl]-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322190 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 4-(5-hydroxy-pyridin-2-yl)-benzonitrile (Preparation 22) and 3-iodomethyl-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 15) to afford the racemate as a white solid (149 mg, 85.2%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ca830f1ccbad4095867350d5c1713a8c |
| Source note | uspto-grants-2012_10 |