HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Hydroxy-4-biphenylcarbonitrile → 3-(4'-Cyano-biphenyl-4-yloxymethyl)-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Hydroxy-4-biphenylcarbonitrile | HCID 140610 | — |
| Reactant | 3-Iodomethyl-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322172 | — |
| Product | 3-(4'-Cyano-biphenyl-4-yloxymethyl)-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322184 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 4′-hydroxy-4-biphenyl carbonitrile and 3-iodomethyl-1-(2-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 15) to afford the racemate as a white solid (157 mg, 66%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-9f0eeb0637a3420ba137853c93a8b989 |
| Source note | uspto-grants-2012_10 |