4-Fluoro-4'-hydroxybiphenyl → 1-(2-Ethoxy-benzoyl)-3-(4'-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.C(O[C:18]([C:20]1(CI)[CH2:24][CH2:23][N:22]([C:25](=[O:35])[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[O:32][CH2:33][CH3:34])[CH2:21]1)=O)C>>[CH2:33]([O:32][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[C:25]([N:22]1[CH2:23][CH2:24][CH:20]([CH2:18][O:14][C:11]2[CH:12]=[CH:13][C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[CH:9][CH:10]=2)[CH2:21]1)=[O:35])[CH3:34]Participants
3
Procedure
The title compound was prepared according to the method described for Preparation 29 using 4′-fluoro-biphenyl-4-ol and 1-(2-ethoxy-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 16) to afford the racemate as a white solid (191 mg, 70%)
Sources & evidence
- ORD record
- ord-40a096ef40a64366ae07697999c1650c
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08278343B2
Reaction notes
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