Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(4-Chlorophenyl)pyrimidin-5-ol → 3-[2-(4-Chloro-phenyl)-pyrimidin-5-yloxymethyl]-1-(2-ethoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(4-Chlorophenyl)pyrimidin-5-ol | HCID 59322178 | — |
| 반응물 | 1-(2-Ethoxy-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322228 | — |
| 생성물 | 3-[2-(4-Chloro-phenyl)-pyrimidin-5-yloxymethyl]-1-(2-ethoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322200 | — |
반응 단계
The title compound was prepared according to the method described for Preparation 29 using 2-(4-chloro-phenyl)-pyrimidin-5-ol (Preparation 27) and 1-(2-ethoxy-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 16) to afford the racemate as a white solid (238 mg, 83.9%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08278343B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-636793c06e3f4ad6843834bf720697ae |
| 출처 메모 | uspto-grants-2012_10 |