HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodomethyl-1-(4-methoxy-benzoyl) pyrrolidine-3-carboxylic acid ethyl ester → 3-[5-(4-Chloro-phenyl)-pyrazin-2-yloxymethyl]-1-(4-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodomethyl-1-(4-methoxy-benzoyl) pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322193 | — |
| Reactant | HCID 178516753 | HCID 178516753 | — |
| Product | 3-[5-(4-Chloro-phenyl)-pyrazin-2-yloxymethyl]-1-(4-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322167 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 5-(4-chloro-phenyl)-pyrazin-2-ol (Preparation 25) and 3-iodomethyl-1-(4-methoxy-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 14) to afford the racemate as a white solid (44 mg, 22%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-30ae2b3fe9124ae2a571f56cded40e5b |
| Source note | uspto-grants-2012_10 |