HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-4'-hydroxybiphenyl → 1-(4-Fluoro-benzoyl)-3-(4'-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-4'-hydroxybiphenyl | HCID 345420 | — |
| Reactant | 1-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322211 | — |
| Product | 1-(4-Fluoro-benzoyl)-3-(4'-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322209 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 4′-fluoro-biphenyl-4-ol and 1-(4-fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 12) to afford the racemate as a white solid (150 mg, 73%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-c641620ed43b4a039ccbc7e2e9f4b1f6 |
| Source note | uspto-grants-2012_10 |