2,3-Difluorophenol → 3-(2,3-Difluoro-phenoxymethyl)-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

HRID 2060289노트

반응식

HRID 2060289 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([O:12][C:13]([C:15]1([CH2:29]I)[CH2:19][CH2:18][N:17]([C:20](=[O:28])[C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:16]1)=[O:14])[CH3:11]>>[CH2:10]([O:12][C:13]([C:15]1([CH2:29][O:9][C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[CH2:19][CH2:18][N:17]([C:20](=[O:28])[C:21]2[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=2)[CH2:16]1)=[O:14])[CH3:11]

참가 물질

3

반응물 2

HCID 808792,3-DifluorophenolHCID 593222111-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester

생성물 1

HCID 593221683-(2,3-Difluoro-phenoxymethyl)-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

실험 절차

The title compound was prepared according to the method described for Preparation using 2,3-difluoro-phenol and 1-(4-fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 12) to afford the racemate as a white solid (167 mg, 68%) ES m/z 408 [MH]+

후처리

  1. customdescribed for Preparation

출처 및 근거

ORD 기록
ord-46220e9550e6436787c6e65398ee51a5
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08278343B2

반응 노트

불러오는 중…