HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-fluorophenol → 3-(3-Chloro-4-fluoro-phenoxymethyl)-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-fluorophenol | HCID 75790 | — |
| Reactant | 1-(4-Fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322211 | — |
| Product | 3-(3-Chloro-4-fluoro-phenoxymethyl)-1-(4-fluoro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester | HCID 59322194 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 29 using 3-chloro-4-fluoro-phenol and 1-(4-fluoro-benzoyl)-3-iodomethyl-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 12) to afford the racemate as a white solid (153 mg, 69%) ES m/z 424 [MH]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278343B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-823f7071ce004145bbe1acc8c5528092 |
| Source note | uspto-grants-2012_10 |