4-Chlorophenyl Isocyanate → HCID 59322196, compound

HRID 2060295Notes

Reaction equation

HRID 2060295 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[CH2:11]([O:13][C:14]([C:16]1([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)=[CH:25][CH:24]=2)[CH2:20][CH2:19][NH:18][CH2:17]1)=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1([CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=3)=[CH:25][CH:24]=2)[CH2:20][CH2:19][N:18]([C:9](=[O:10])[NH:8][C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH2:17]1)=[O:15])[CH3:12]

Participants

3

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 593221953-(4'-Fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester

Product 1

HCID 59322196HCID 59322196, compound

Procedure

The title compound was prepared according to the method described for Preparation using 4-chloro phenyl isocyanate and 3-(4′-fluoro-biphenyl-4-yloxymethyl)-pyrrolidine-3-carboxylic acid ethyl ester (Preparation 65) to afford the racemate as a white solid (220 mg, 76%)

Workup

  1. customdescribed for Preparation

Sources & evidence

ORD record
ord-d2763e3551a4487ca3c3a76252955ba5
Source dataset
uspto-grants-2012_10
Patent number
US08278343B2

Reaction notes

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