HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2060301Generated: November 1, 2026
4-Methylbenzaldehyde → 3-Hydroxy-1-(3-imidazol-1-yl-propyl)-4-phenyl-5-p-tolyl-1,5-dihydro-pyrrol-2-one
https://huagongshe.com/reaction/2060301
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylbenzaldehyde | HCID 7725 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | Ethyl 2-oxo-3-phenylpropanoate | HCID 12292599 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Hydroxy-1-(3-imidazol-1-yl-propyl)-4-phenyl-5-p-tolyl-1,5-dihydro-pyrrol-2-one | HCID 25099446 | — |
Reaction Steps
3-Imidazol-1-yl-propylamine (1 mmol) and 4-Methyl-benzaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-3-phenyl-propionic acid ethylester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08278345B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-475a63bf865e41c189346b7a276f3402 |
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| Source note | uspto-grants-2012_10 |
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