Acrolein dimer → HCID 57924258, compound

HRID 2060315Notes

Reaction equation

[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH:11]1[CH:16]=O.C([O:20][C:21](=O)[C:22](=[O:31])[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=1)C>C(O)C>[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH:11]1[CH:16]1[N:9]([CH2:8][CH2:7][CH2:6][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[C:21](=[O:20])[C:22]([OH:31])=[C:23]1[C:24]1[CH:25]=[CH:26][C:27]([OH:30])=[CH:28][CH:29]=1

Participants

Conditions

Temperature: 50 °C

Procedure

3-Imidazol-1-yl-propylamine (1 mmol) and 3,4-Dihydro-2H-pyran-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 3-(4-Hydroxy-phenyl)-2-oxo-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

customAfter evaporation of the solvent the residue
customwas purified with chromatographic methods

Sources & evidence

ORD record: ord-3eb8d76a930649fc817ab5e762992125
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08278345B2

Reaction notes

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