HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2060319Generated: November 2, 2026
2-Thiophenecarboxaldehyde → 3-Hydroxy-1-(3-imidazol-1-yl-propyl)-4-pentyl-5-thiophen-2-yl-1,5-dihydro-pyrrol-2-one
https://huagongshe.com/reaction/2060319
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| Reactant | 1H-Imidazole-1-propanamine | HCID 78736 | — |
| Reactant | Ethyl 2-oxooctanoate | HCID 10888659 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Hydroxy-1-(3-imidazol-1-yl-propyl)-4-pentyl-5-thiophen-2-yl-1,5-dihydro-pyrrol-2-one | HCID 57924241 | — |
Reaction Steps
3-Imidazol-1-yl-propylamine (1 mmol) and Thiophene-2-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2-Oxo-octanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08278345B2 |
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| Source dataset | uspto-grants-2012_10 |
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| ORD ID | ord-19ab193a302449868c5db915f9621805 |
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| Source note | uspto-grants-2012_10 |
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