2,1,3-Benzothiadiazole-5-carbaldehyde → HCID 178516882, compound

HRID 2060326Notes

Reaction equation

HRID 2060326 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]1[S:15][N:14]=[C:13]2[CH:16]=[C:17]([CH:20]=O)[CH:18]=[CH:19][C:12]=12.C([O:24][C:25](=O)[C:26](=[O:35])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([OH:34])[CH:29]=1)C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:20]([C:17]4[CH:18]=[CH:19][C:12]5=[N:11][S:15][N:14]=[C:13]5[CH:16]=4)[C:27]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([OH:34])[CH:29]=4)=[C:26]([OH:35])[C:25]3=[O:24])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 27762902,1,3-Benzothiadiazole-5-carbaldehydeHCID 21480047HCID 21480047, compoundHCID 178507353HCID 178507353, compound

Product 1

HCID 178516882HCID 178516882, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and Benzo[1,2,5]thiadiazole-5-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 3-(3-Hydroxy-phenyl)-2-oxo-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-f6456b5fc8d84166b4872dc19d1925a8
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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