Ethyl 2,4-dioxovalerate → HCID 178467289, compound

HRID 2060331Notes

Reaction equation

HRID 2060331 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:11][C:12]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:13]=1[CH:14]=O.C([O:23][C:24](=O)[C:25](=[O:30])[CH2:26][C:27](=[O:29])[CH3:28])C>C(O)C>[C:27]([C:26]1[CH:14]([C:13]2[CH:16]=[CH:17][CH:18]=[C:19]([F:20])[C:12]=2[F:11])[N:10]([C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)[C:24](=[O:23])[C:25]=1[OH:30])(=[O:29])[CH3:28]

Participants

5

Reactant 3

HCID 69208Ethyl 2,4-dioxovalerateHCID 1376642,3-DifluorobenzaldehydeHCID 178507353HCID 178507353, compound

Product 1

HCID 178467289HCID 178467289, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and 2,3 Difluorobenzaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2,4-Dioxo-pentanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-7a906d7ea21e41ec957f9b65360b61ee
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

Loading…