Ethyl 2,4-dioxovalerate → HCID 178467285, compound

HRID 2060339Notes

Reaction equation

HRID 2060339 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[Br:11][C:12]1[CH:13]=[CH:14][C:15]([F:20])=[C:16]([CH:19]=1)[CH:17]=O.C([O:23][C:24](=O)[C:25](=[O:30])[CH2:26][C:27](=[O:29])[CH3:28])C>C(O)C>[C:27]([C:26]1[CH:17]([C:16]2[CH:19]=[C:12]([Br:11])[CH:13]=[CH:14][C:15]=2[F:20])[N:10]([C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)[C:24](=[O:23])[C:25]=1[OH:30])(=[O:29])[CH3:28]

Participants

5

Reactant 3

HCID 69208Ethyl 2,4-dioxovalerateHCID 7363275-Bromo-2-fluorobenzaldehydeHCID 178507353HCID 178507353, compound

Product 1

HCID 178467285HCID 178467285, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and 5-bromo-2-fluorobenzaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 2,4-Dioxo-pentanoic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-af8395d3fdff469c95ba2eaa85d8c4c6
Source dataset
uspto-grants-2012_10
Patent number
US08278345B2

Reaction notes

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