N-3-Bromopropylphthalimide → 2-[3-(2'-oxo-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-1'(2'H)-yl)propyl]-1H-isoindole-1,3(2H)-dione

HRID 206034Notes

Reaction equation

HRID 206034 reaction equation
[Br:16][CH2:17][c:18]1[o:19][c:20]([C:21]([F:22])([F:23])[F:24])[cH:25][cH:26]1.[Br:1][CH2:2][CH2:3][CH2:4][N:5]1[C:6](=[O:15])[c:7]2[c:8]([cH:11][cH:12][cH:13][cH:14]2)[C:9]1=[O:10].[CH3:48][c:49]1[c:50]2[cH:51][c:52]3[c:65]([cH:66][c:67]2[o:68][n:69]1)[O:64][CH2:63][C:53]31[c:54]2[c:55]([cH:56][cH:57][cH:58][cH:59]2)[NH:60][C:61]1=[O:62].[NH:27]1[C:28](=[O:47])[C:29]2([c:30]3[c:31]([cH:34][c:35]4[c:39]([cH:40]3)[CH2:38][CH2:37][O:36]4)[O:32][CH2:33]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][c:46]21>>[CH2:2]([CH2:3][CH2:4][N:5]1[C:6](=[O:15])[c:7]2[c:8]([cH:11][cH:12][cH:13][cH:14]2)[C:9]1=[O:10])[N:27]1[C:28](=[O:47])[C:29]2([c:30]3[c:31]([cH:34][c:35]4[c:39]([cH:40]3)[CH2:38][CH2:37][O:36]4)[O:32][CH2:33]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][c:46]21

Participants

5

Reactant 4

HCID 21611N-3-BromopropylphthalimideHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-oneHCID 593524533-methylspiro[furo[3,2-f][1,2]benzisoxazole-5,3'-indol]-2'(1H)-one

Product 1

HCID 593525442-[3-(2'-oxo-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-1'(2'H)-yl)propyl]-1H-isoindole-1,3(2H)-dione

Sources & evidence

ORD record
ord-c10a4a56490d4a29a9763791d6d20b62
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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