Methyl (S)-(-)-2-Isocyanato-3-methylbutyrate → Methyl N-{[(1,1-dimethylpent-4-en-1-yl)amino]carbonyl}-L-valinate

Participants

Reaction Steps

Methyl N-(oxomethylene)-L-valinate (2.80 g, 17.7 mmol) was added to 2-methylhex-5-en-2-amine [J. Org. Chem. (1976) 41(5) 855-863.] (2.00 g, 17.7 mmol) in THF (15 mL). After 5 minutes, the reaction mixture was evaporated to give the title compound as a solid which was triturated with hexane and isolated by filtration (2.71 g). LRMS (M+H)+=271.4.

Provenance & Evidence