Hydrochloric Acid → HCID 66963131, compound

Participants

Reaction Steps

To a solution of 1-tert-butyl 2-methyl (2S,4R)-4-[(6-bromoquinazolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate (3.46 g, 6.65 mmol) in dioxane (80 mL) at 0° C. was introduced anhydrous HCl (g) over 30 min. The reaction was complete by HPLC/MS. The reaction mixture was concentrated and the resulting solids were azeotroped with diethyl ether (50 mL) to give the title compound (3.0 g). LRMS (M+H)+=352.2.

Provenance & Evidence