HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid → (S)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid | HCID 11020520 | — |
| Reactant | H-Ser(tBu)-OtBu HCl | HCID 16211506 | — |
| Product | (S)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-3-hydroxy-propionic acid | HCID 86595449 | — |
Reaction Steps
Prepared in analogy to Example A-2 e) and f) from 1-chloro-4-hydroxy-isoquinoline-3-carboxylic acid from Example A-2 d) and (S)-2-amino-3-tert-butoxy-propionic acid tert-butyl ester hydrochloride; MS-(+)-ion: M+1=310.9 amu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278325B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-349a8647ef664993a00d3d0cb4df2561 |
| Source note | uspto-grants-2012_10 |