HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl D-alaninate → (R)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl D-alaninate | HCID 89020 | — |
| Reactant | 1-Chloro-4-hydroxyisoquinoline-3-carboxylic acid | HCID 11020520 | — |
| Product | (R)-2-[(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester | HCID 86595457 | — |
Reaction Steps
1-Chloro-4-hydroxy-isoquinoline-3-carboxylic acid, 0.55 g, was coupled with 0.40 g of D-Alanine methyl ester analogously to Example A-54 a) and 0.200 g of off-white, solid product were obtained: MS-(+)-icon, M+1=308.8 amu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278325B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-bc63eeef0eec4f6481726902bd4023f2 |
| Source note | uspto-grants-2012_10 |